DNA Repair: Mechanisms and Clinical Significance

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The collection of processes required to identify and correct the damage in the DNA molecules is known as DNA repair. DNA damage can be caused by metabolic activities and environmental factors. Cells are not able to function properly if the integrity and accessibility of essential information gets corrupted by DNA damage. So, to restore the correct information, various strategies have been evolved according to the type of damage occurred in the double helical structure of DNA. Some of these mechanisms are single-strand damage, double-strand breaks, direct reversal, and translesion synthesis. In...

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